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Studies designed to provide insight into clinical practice in the real world are referred to as pragmatic trials. They are typically characterized by a focus on the practical aspects of the study design, such as recruitment and consent, adherence, and the use of standard equipment.
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Another example of a pragmatic trial is the Home Blood Pressure Management (HBPM) study, which employed various investigators and participants from different geographic areas. This type of heterogeneity, that is crucial for pragmatic trials to be reliable and lessen the chance of bias is also essential. However too much heterogeneity could cause problems with the design of the trial.
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Mobile compatibility
Pragmatic Play is a relatively new player in the world of online casinos however, it has already made a name for itself by offering mobile-friendly slots. Their games are optimized for mobile devices, and run using HTML5 technology. They are also licensed and regulated by reputable gaming authorities, which ensure fairness and transparency. This is a good signal for players since it means the games have been tested and validated to ensure randomness and unbiased results of every round.
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Legality
Pragmatic Play has gained a reputation for offering high-quality games and a superior user experience. Its software is designed to work with mobile devices and is compatible with multiple languages. Despite its infancy it has already established itself as a premier casino gaming platform. Its latest releases include Wolves which is a five-reel video slot with a healthy RTP and stunning graphics. Other notable titles include Wolf Gold and Chilli Heat.
Pragmatic trials aim to mimic real-life situations and attain maximum external validity. They are usually commissioned by practitioners and policy makers to inform their decision making. They can also be used to assess the causal relationship between an intervention and its results. However, they shouldn't be used as a substitute for explanation studies.
The pragmatism idea is controversial and there are doubts about whether pragmatic trials can replace explanatory tests or if they should be an alternative to them. Schwartz and Lellouch1 suggested a distinction between explanatory studies, which confirm a physiological hypothesis or clinical hypothesis, as well as pragmatic trials, which inform the decision-making process for policy and practice. They also suggested a framework for pragmatic trials, called PRECIS.2 This tool sought to define the elements of a practical trial, including the recruitment process, the design and implementation of the intervention, and the follow-up.
There is a growing increase in the number of pragmatic trials that are published. A recent Medline search using the terms naturalistic and pragmatic, limited to controlled trials that are randomized (RCTs) resulted in 34 articles, shown in red in Figure 2. This indicates that the health sciences community has become more aware of the importance of pragmatism. It is important to note that the majority of studies were conducted in primary care settings.